Trials Today

• Have signs and/or symptoms or documented diagnosis of Psoriatic Arthritis (PsA) for at least 6 months and currently fulfilling the classification of Psoriatic Arthritis (CASPAR) criteria. - Have active PsA, defined as the presence of at least 3 of 68 tender joints and at least 3 of 66 swollen joints. - Have obesity, body mass index of ≥30 kilograms per meter squared (BMI ≥30 kg/m²) or overweight (BMI ≥27 to <30 kg/m²) in the presence of at least 1 of these weight-related comorbid conditions (hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2DM).

Medical Conditions - Have Type 1 Diabetes Mellitus (T1DM). - Have insulin-treated Type 2 Diabetes Mellitus (T2DM). - Have a prior or planned surgical treatment for obesity. - Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia (MEN) syndrome type 2. - Have active, or a history of inflammatory bowel disease (Crohn's or ulcerative colitis). - Have a diagnosis or history of malignant disease within the 5 years prior to randomization, with the following exceptions: - basal cell or squamous epithelial carcinomas of the skin that have been resected, with no evidence of metastatic disease for 3 years. - cervical carcinoma in situ, with no evidence of recurrence within the 5 years prior to randomization. - Have a serious disorder or illness other than PsA. - Have a history of chronic or acute pancreatitis. - Have any prior use of ixekizumab or tirzepatide. - Diagnosis of other inflammatory arthritis, such as Rheumatoid Arthritis (RA), ankylosing spondylitis, reactive arthritis, gout, or enteropathic arthritis. - Have a previous failure or intolerance to an interleukin 17 inhibitor (IL-17i) or glucagon-like peptide 1 (GLP-1) receptor agonists.